Regenerative medicine for fertility at Femcare Fertility, Kalyani Nagar, Pune uses platelet-rich plasma (PRP) and growth factor therapies to address thin endometrium and poor ovarian response under Dr. Sayali Chavan Shitole's guidance. Treatment candidacy is assessed individually based on investigation findings. Consultation: ₹500.
Regenerative medicine is a broad field that uses the body's own repair mechanisms - or carefully prepared biological materials - to restore function in damaged tissue. In fertility medicine, it is being applied to two specific and difficult problems: a uterine lining that does not grow thick enough for embryo implantation and ovaries whose function has declined or failed prematurely.
At Femcare Fertility in Kalyani Nagar, Pune, Dr. Sayali Chavan Shitole takes a measured, evidence-conscious approach to regenerative therapies. She does not present these treatments as miracle solutions, but she does offer them to carefully selected patients as part of a broader plan when conventional approaches have reached their limit.
Platelet-Rich Plasma (PRP) therapy - prepared from the patient's own blood by centrifugation, concentrating growth factors that stimulate tissue repair and regeneration
Growth factor infusions - targeted application of specific proteins that signal cell regeneration
Exosome therapy - a more experimental approach using cell-derived vesicles carrying regenerative signals, currently under active research
For embryo implantation to succeed, the endometrium (uterine lining) must be at least 7-8mm thick and show a trilaminar appearance on ultrasound. A significant minority of IVF patients - particularly those with prior uterine surgery, infections, or Asherman's syndrome - have a chronically thin endometrium that does not respond adequately to oestrogen therapy.
Intrauterine PRP infusion delivers concentrated growth factors directly to the endometrial tissue, stimulating cell proliferation and improving blood supply to the lining. Clinical reports from reproductive medicine centres show improvements in endometrial thickness and higher embryo transfer completion rates in women who previously had cancelled transfers due to thin lining.
The concept of stimulating dormant ovarian follicles in women with significantly diminished or absent ovarian function using PRP or growth factor injection has attracted considerable scientific interest. Several research groups have published cases of women with premature ovarian insufficiency who developed detectable follicles, underwent egg retrieval and achieved pregnancy following ovarian PRP.
However, the sample sizes in these studies are small and the treatment does not work for everyone. Dr. Sayali presents ovarian rejuvenation as an option to be considered in the context of a full discussion of the evidence, alternative options (including donor eggs) and the emotional and financial implications of pursuing an investigational treatment.
PRP and growth factor therapies use biological materials derived from the patient's own blood - no cell transplantation is involved. True stem cell therapy involves harvesting cells with differentiation potential and infusing them into target tissue. Both fall under the umbrella of regenerative medicine and some clinics use the terms interchangeably. Dr. Sayali is precise about the distinction and about the evidence for each.
Confirmed thin endometrium ( "<" 7mm despite adequate oestrogen priming over multiple cycles)
History of uterine surgery or infection explaining endometrial scarring
Premature ovarian insufficiency with FSH > 40, absent periods and very low or undetectable AMH
Previous failed IVF cycles where endometrial factors are the most likely explanation